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Bing's US Market Share Is Wildly Underestimated. Microsoft claims Bing, its search engine for people who have just unboxed a new computer and are trying to find out where to download Chrome, is bigger than you think. Stats released by the company this week claim Bing enjoys an astonishing 3. US, which is far higher than the frankly more believable 9 percent it reports worldwide. According to Microsoft, the 3. This is surprising, because as Ars Technica’s Peter Bright noted, the most common reaction he gets when he says he uses the site at all is slack- jawed stares and stupid questions. I, for one, can’t remember a single time I’ve used Bing in recent memory, other than the aforementioned use of installing a web browser that doesn’t use Bing. If Microsoft’s metrics are to be believed, it’s quite a coup: Half a decade ago, some rankings had it come in at under 3 percent of global searches. The numbers seem to go up and down depending on the source, but the most generous prior estimate (from Comscore last year) put Microsoft at just north of 2. Bing technology powers Yahoo’s search engine. None of that counts mobile queries, where Google has a functional global monopoly with virtually no meaningful competition whatsoever. So few web- savvy people seem to use Bing that those who do are a sort of curiosity, though that might just be compartmentalization: If you’re a heavy Google user, using Chrome tied to a Gmail account, it might not ever occur to you that Bing even exists. But since the vast majority of new computer sales are for Windows devices, which come preloaded with Bing- defaulting browsers Internet Explorer or Edge, one would imagine there’s enough workplace users, old people, folks who don’t give a damn and others of their ilk to make up a big share of the market. They’re real and they’re out there, just Binging it up, occasionally not noticing sand penises.[Ars Technica]. Shop for the latest software and technology products from Microsoft Store. Experience the best of Microsoft with easy online shopping. Microsoft claims Bing, its search engine for people who have just unboxed a new computer and are trying to find out where to download Chrome, is bigger than you think. I blame Adobe for this. Ulysses, one of the best writing tools available right now, is going subscription only. If you previously purchased Ulysses for Mac or iOS (it.Cloud Computing Security Considerations: ASD Australian Signals Directorate. ASD > Publications > Cloud Computing Security Considerations. Download CSOC Protect Notice, Cloud Computing Security Considerations (PDF), updated September 2. First published 2. September 2. 01. 2Note: Newer, more detailed Cloud Computing Security advice is available. Introduction. Cloud computing offers potential benefits including cost savings and improved business outcomes for Australian government agencies. However, there are a variety of information security risks that need to be carefully considered. Risks will vary depending on the sensitivity of the data to be stored or processed, and how the chosen cloud vendor (also referred to as a cloud service provider) has implemented their specific cloud services. This discussion paper assists agencies to perform a risk assessment to determine the viability of using cloud computing services. Microsoft Office 365 Identities and Requirements is a certification exam focused on the administration of a Microsoft Office 365 tenant in a corporate environment. InformationWeek.com: News, analysis and research for business technology professionals, plus peer-to-peer knowledge sharing. Engage with our community. This document provides an overview of cloud computing and associated benefits. Most importantly, this document provides a list of thought- provoking questions to help agencies understand the risks that need to be considered when using cloud computing. Developing a risk assessment helps senior business representatives make an informed decision as to whether cloud computing is currently suitable to meet their business goals with an acceptable level of risk. The questions in this document address the following topics. The Australian Signals Directorate (ASD) strongly encourages both senior managers and technical staff to work through this list of questions together. The questions are intended to provoke discussion and help agencies identify and manage relevant information security risks associated with the evolving field of cloud computing. In particular, the risk assessment needs to seriously consider the potential risks involved in handing over control of your data to an external vendor. Risks may increase if the vendor operates offshore. This document complements the advice on cloud computing in the Australian Government Information Security Manual (ISM). ASD recommends against outsourcing information technology services and functions outside of Australia, unless agencies are dealing with data that is all publicly available. ASD strongly encourages agencies to choose either a locally- owned vendor or a foreign- owned vendor that is located in Australia and stores, processes and manages sensitive data only within Australian borders. Note that foreign- owned vendors operating in Australia may be subject to foreign laws such as a foreign government’s lawful access to data held by the vendor. Overview of cloud computing. Cloud computing as a delivery model for IT services is defined by the US National Institute of Standards and Technology (NIST) as “a model for enabling ubiquitous, convenient, on- demand network access to a shared pool of configurable computing resources (e. NIST Special Publication 8. NIST Definition of Cloud Computing (PDF)]. NIST specify five characteristics of cloud computing. On- demand self- service involves customers using a web site or similar control panel interface to provision computing resources such as additional computers, network bandwidth or user email accounts, without requiring human interaction between customers and the vendor. Broad network access enables customers to access computing resources over networks such as the Internet from a broad range of computing devices such as laptops and smartphones. Resource pooling involves vendors using shared computing resources to provide cloud services to multiple customers. Virtualisation and multi- tenancy mechanisms are typically used to both segregate and protect each customer and their data from other customers, and to make it appear to customers that they are the only user of a shared computer or software application. Rapid elasticity enables the fast and automatic increase and decrease to the amount of available computer processing, storage and network bandwidth as required by customer demand. Pay- per- use measured service involves customers only paying for the computing resources that they actually use, and being able to monitor their usage. This is analogous to household use of utilities such as electricity. There are three cloud service models. A non- exhaustive list of example vendor services is provided to help the reader understand the cloud service models. Inclusion of an example vendor service does not imply ASD’s support of the service. Infrastructure as a Service (Iaa. S) involves the vendor providing physical computer hardware including CPU processing, memory, data storage and network connectivity. The vendor may share their hardware among multiple customers referred to as “multiple tenants” using virtualisation software. Iaa. S enables customers to run operating systems and software applications of their choice. Typically the vendor controls and maintains the physical computer hardware. Typically the customer controls and maintains the operating systems and software applications. Example Iaa. S vendor services include Amazon Elastic Compute Cloud (EC2), Go. Grid and Rackspace Cloud. Windows Server 2003, Windows Server 2003 SP1 and SP2, and Windows Server 2003 R2 retired content. The content you requested has already retired. It's available to.Platform as a Service (Paa. S) involves the vendor providing Infrastructure as a Service plus operating systems and server applications such as web servers. Paa. S enables customers to use the vendor’s cloud infrastructure to deploy web applications and other software developed by the customer using programming languages supported by the vendor. Typically the vendor controls and maintains the physical computer hardware, operating systems and server applications. Typically the customer only controls and maintains the software applications developed by the customer. Example Paa. S vendor services include Google App Engine, Force. Amazon Web Services Elastic Beanstalk and the Microsoft Windows Azure platform. Software as a Service (Saa. S) involves the vendor using their cloud infrastructure and cloud platforms to provide customers with software applications. Example applications include email and an environment for users to collaboratively develop and share files such as documents and spreadsheets. These end- user applications are typically accessed by users via a web browser, eliminating the need for the user to install or maintain additional software. Typically the vendor controls and maintains the physical computer hardware, operating systems and software applications. Typically the customer only controls and maintains limited application configuration settings specific to users such as creating email address distribution lists. Example Saa. S vendor services include Salesforce. Customer Relationship Management (CRM), Google Docs and Google Gmail. Microsoft Office 3. Business Productivity Online Suite) consists of Microsoft Office Web Apps, Microsoft Exchange Online, Microsoft Share. Point Online, Microsoft Dynamics CRM Online and Microsoft Lync. A vendor adding the words “cloud” or “as a Service” to the names of their products and services does not automatically mean that the vendor is selling cloud computing as per the NIST definition. There are four cloud deployment models. Public cloud involves an organisation using a vendor’s cloud infrastructure which is shared via the Internet with many other organisations and other members of the public. This model has maximum potential cost efficiencies due to economies of scale. However, this model has a variety of inherent security risks that need to be considered. Private cloud involves an organisation’s exclusive use of cloud infrastructure and services located at the organisation’s premises or offsite, and managed by the organisation or a vendor. Compared to the public cloud model, the private cloud model has reduced potential cost efficiencies. If the private cloud is properly implemented and operated, it has reduced potential security concerns. A well- architected private cloud properly managed by a vendor provides many of the benefits of a public cloud, but with increased control over security. A managed private cloud may enable enterprise customers to more easily negotiate suitable contracts with the vendor, instead of being forced to accept the generic contracts designed for the consumer mass market that are offered by some public cloud vendors. Community cloud involves a private cloud that is shared by several organisations with similar security requirements and a need to store or process data of similar sensitivity. Cloud- Based Hospital Information System as a Service for Grassroots Healthcare Institutions. Poon, E. G., Jha, A. K., Christino, M., Honour, M. M., Fernandopulle, R., Middleton, B., Newhouse, J., Leape, L., Bates, D. W., and Blumenthal, D., Assessing the level of healthcare information technology adoption in the United States: a snapshot. BMC Medical Informatics and Decision Making 6(1): 1, 2. Cross. Ref. Google Scholar. Transportation in the Philippines | Springer. Link. Linking the islands of the archipelago was traditionally done by boat. Today, ships are still used by millions of people to cross straits between the major islands, since there are no bridges except from Leyte to Samar. We would like to show you a description here but the site won’t allow us. 9:09 am I.D. Systems acquires Keytroller, a manufacturer and marketer of electronic products for managing forklifts, construction vehicles, and other industrial. 9780867168419 0867168412 Quiet Moments with Padre Pio - 120 Daily Readings, Patricia Treece 9781933693248 193369324X Charro Claus and the Tejas Kid, Xavier Garza. Cebu lies at the center of the ferries network, while small bangkas bring people to remote islets or through river mouths and harbors. The implementation of the Strong Republic Nautical Highway aims at speeding up and smoothing transfers from island to island.The port of Manila, a small player in the dynamic West Pacific rim, may be relieved from congestion with the rise of Batangas and Subic.Aviation, centered at the saturated Manila airport, has grown quickly since deregulation pitted new entrants (Cebu Pacific) against the well- established Philippine Airlines.A good part of intercity travel is done with buses, since the country has almost no rail transport today. At the local level, mobility is done with quintessential Philippine vehicles: the jeepney (sometimes transformed in a masterpiece of pop art), the trisikel, the pedicab or the skates. Today, efforts are underway to transform the system by introducing clean electric vehicles and reforming the rules of for- hire transportation, despite strong oppositions. Germany Germany site information (The locations and units in this German section have been made the same as Rolf Dieter G?rigk's former web page "GPS Locations of. Statistical Techniques | Statistical Mechanics. Nike People. Germany. Germany site information (The locations and units in this German section have been made the same as. Rolf Dieter G? rigk's. GPS Locations of Former NIKE Sites in Germany". Sites & units are organized from north to south. Google Earth set up for. German Nike sites (as of June 2. Rolf Dieter G? rigk. You will need to have "Google Earth" loaded to view these. Spotted by Thomas Olson and Thomas Page. This page gives a link to site with maps of German AA defense sites. Early NATO document about NIKE in Europe. AIR DEFENSE 1. 95. Spotted by Thomas Page. Not all European Nike Sites did their annual refire from Crete or Sardinia. Jan Korver provided an old order for a Netherlands unit. Ft. Bliss. (I obscured some serial # info), 1 MByte, added Aug 1. Firing Batteries and their Head. Quarters. Northern Area. Fla. Rak. Btl 2. 4. Fla. Rak. Btl 2. 5. Fla. Rak. Btl 2. 6North Central Area. Group Guided Weapons (Netherlands)Central Area. Msl Btn (Belgian). Msl Btn (Belgian).Fla. Rak. Btl 2. 3South Central Area. Btn 1st ADA. 4th Btn 6th ADA.Btn 6th ADA. 1st Btn 6. ADASouth Area. 2nd Btn 5. ADA. 3rd Btn 7. 1st ADA. Far South Area. 5. French). 5. 21th (French)Other unitshere. Please Note: The "special warheads" were physically under U. S. military control. Nike units that were manned by other nations had U. S. troops physically present. The U. S. units had different unit names than the. For an explanation of the dual role, please see. US Army units on NATO Countries Batteries. Richard Scheffler. Further comments. DSP" means "Direct Support Platoon". Implementation of Quantitative and Systems Pharmacology in Large Pharma. CPT Pharmacometrics Syst Pharmacol. Oct; 3(1. 0): e. 14. Beyond Compare is a multi-platform utility that combines directory compare and file compare functions in one package. Use it to manage source code, keep directories. 2-Oct-2014 Addendum-Page 1 PACKAGING INFORMATION Orderable Device Status (1) Package Type Package Drawing Pins Package Qty Eco Plan (2) (5). An electronic flight instrument system (EFIS) is a flight deck instrument display system that displays flight data electronically rather than electromechanically. Quantitative Pharmacology and Pharmacometrics, Merck Research Labs, Merck & Co, Rahway, New Jersey, USA2. Quantitive Pharmacology and Pharmacometrics, MSD, Oss, The Netherlands. Received 2. 01. 4 Jun 1. Accepted 2. 01. 4 Jul 3. Copyright © 2. 01. American Society for Clinical Pharmacology and Therapeutics. This work is licensed under a Creative Commons Attribution 3. Unported License The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http: //creativecommons. This article has been cited by other articles in PMC. Abstract. Quantitative and systems pharmacology concepts and tools are the foundation of the model- informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. Rigorous prioritization of modeling and simulation activities has enabled key drug development decisions and led to a high return on investment through significant cost avoidance. Critical factors for the successful implementation, examples on impact on decision making with associated return of investment, and drivers for continued success are discussed. Quantitative and Systems Pharmacology in Drug Discovery and Development. Systematic application of a model- based drug development paradigm has been identified as a valuable approach to reverse the continued decline of R& D productivity by shifting compound attrition from late clinical development to earlier stages, ensuring more robustly designed studies, delivering against go/no go criteria, and improving confidence in the compound. Model- based (or better stated as model- informed)7 drug development encompasses the utilization of a “quantitative toolkit” in clinical development that includes pharmacokinetic–pharmacodynamic models, disease models, comparator models, model- based meta- analysis approaches, trial design simulations, quantitative decision criteria, and performance metrics. More recently, the application area of model- based analyses has expanded into drug discovery and commercialization in by shifting the balance from traditionally used tools such as empirical (population) pharmacokinetics (PK) and pharmacodynamics (PD) models, toward quantitative and systems pharmacology and real- world evidence models. Quantitative and systems pharmacology has been defined by the National Institutes of Health as an approach to translational medicine that combines computational and experimental methods to elucidate, validate, and apply new pharmacological concepts to the development and use of small molecule and biologic drugs. A unique feature of quantitative and systems pharmacology is that it not only provides an integrated system- level approach to determining mechanism of action of new and existing drugs in preclinical and animal models and in patients, but also enables prediction of efficacy and safety of compounds with (novel) mechanisms of action at all stages of drug discovery and development. This emerging discipline has drawn an increasing awareness and focus in recent years. Two National Institutes of Health–sponsored workshops have been held; a white paper was released. Advancements in the computational and experimental techniques have enabled largely systems pharmacology model development within academia, research institutes, and/or specialized technical companies. A focus on the development of system- level (mathematical) models through the integration of experimental data and knowledge has led to an improved understanding of human biology, pharmacology, and safety in multiple disease areas.For example, comprehensive cardiac models are developed that are tailored to the prediction of cardiac liability (see for overview).Within oncology, systems pharmacology approaches were used in quantifying anticancer drug synergy in resistant cells,2.In the diabetes field, a recent review summarized the model contributions over the past five decades. This mathematical modeling, tightly linked to experiments, has had a great impact on the understanding of glucose homeostasis, diabetic condition, and its associated complications. Integration of diabetes modeling efforts also enabled new insights in the underlying mechanisms involved. Moreover, it highlighted the areas where more focused research is required. The application of systems toxicology modeling in drug safety assessment was illustrated by Hoeng. Within the drug industry, quantitative and systems pharmacology has a large emphasis on the application: the integration of knowledge in order to enable decisions and enhane submissions. A wide variety of drug development decisions are amenable to being informed by quantitative systems pharmacology. Examples include: go/no go decisions, dose and schedule selections, optimal trial designs and analysis, comparator differentiation, risk- benefit analysis, discovery target choices, hypothesis testing in in silico models, comparing drug candidate efficacy/safety profiles, predicting human doses, optimal combinations of compounds, and understanding the right patient population. In the submission and life cycle management phase, quantitative and systems pharmacology can support dose justification, bridge between ethnic groups, inform label sections, underpin commercialization strategy, and enable line- extensions. In light of its application, the degree of model complexity is determined by available information and the specific question that needs to be addressed, resulting in a continuum of models ranging from empirical to fully mechanistic models, with often a mixed “middle out” approach. In the pharmaceutical industry context, quantitative and systems pharmacology can, therefore, be considered as the framework that provides the full modeling toolbox that exists within quantitative sciences, supporting the model- informed drug discovery and development paradigm. This modeling toolbox includes models all the way from empirical (e. PK, dose–exposure–response models), (semi- ) mechanistic (e. TMDD), tocomprehensive multidisciplinary (translational) systems models (e. Bayesian model delineation) integrating biological, pharmacological, and clinical knowledge (Figure 1). In this respect, it should be emphasized that systems pharmacology models in an industry setting focus primarily on understanding of the biological pathway/mechanisms of interest and translatable pharmacological pathway interventions that are scalable to humans. Whereas understanding basic PKPD concepts (target site exposure, occupancy, and modulation)4 can enhance the confidence in the compound, systems pharmacology can increase the understanding of efficacy and adverse events in specific diseases and patient populations. In this way, quantitative and systems pharmacology enhances confidence in Proof of Concept, as was elegantly conceptualized by Vicini and Van der Graaf. For this reason, the primary focus of application of quantitative and systems pharmacology in drug discovery and development is to increase the probability of technical success in phase II. Some illustrations of impact examples using quantitative and systems pharmacology in industry are: decision on endometriosis dose management. PKPD behavior for bronchodilatory effect of zileuton, a 5- lipoxygenase inhibitor,3. Within drug industry, quantitative and systems pharmacology focuses on the application: knowledge integration to enable decisions and enhance submissions. The aspiration and benefits of applying quantitative and systems pharmacology value are illustrated.. Merck's Implementation Success Factors. Four years ago, Merck, among other pharmaceutical companies, recognized the need for the implementation of quantitative and systems pharmacology in drug development as a framework for the integration of quantitative knowledge in drug projects. The leading theme for implementation has been to provide timely quantitative answers to critical questions in the development projects in order to enable decision- making. Download Beyond Compare. American Arrested For Using Drone to Smuggle 1. Pounds of Meth From Mexico. President Trump’s proposed wall along the US- Mexico border is stupid for many reasons. But one of the most obvious reasons is that it’s really easy to get over the wall using modern technology. That’s precisely what an American man did recently when he tried to smuggle 1. Tabtight professional, free when you need it, VPN service. This undated photo provided by the US Customs and Border Protection shows a 2-foot-high drone that a border patrol agent spotted swooping over the border fence on. Sometimes a new gadget is just really cool-looking. It hits all the right aesthetic notes, boasts a flashy new technology and looks like something you want. But.Mexico using a hobby drone. The Associated Press reports that an American citizen by the name of Jorge Edwin Rivera has been arrested for transporting methamphetamine into the country using the drone pictured above.Rivera has reportedly told authorities that he’s done it roughly half a dozen times since March, completely undetected.His latest haul was 1.US Customs and Border Protection (CBP) agents spotted the drone near the existing border fence (yes, the US already has walls along the border) at the San Ysidro Port of Entry, close to San Diego.They followed the drone to Rivera, who allegedly had large plastic- wrapped bags of meth on him.Rivera, who’s 2. 5- years- old was just 2,0. It’s unclear how many trips the drone needed to conduct in order to smuggle that much meth over the border. Photos released by CBP suggest that this haul would’ve been the exact weight limit for a single flight. The drone Rivera allegedly used looks like a DJI Matrice 6. Due to the agents’ heightened vigilance, this drone smuggling scheme was stopped before these dangerous narcotics could enter our communities,” said Assistant Chief Patrol Agent Boone Smith in a statement. The meth has a street value of roughly $4. CBP. Rivera is being held without bail and is scheduled to be arraigned September 7th. The suspect reportedly told police that he receives just $1,0. If President Trump is really serious about stopping drugs from crossing the US- Mexico border and he insists that a wall is the only answer, he’s going to need a bigger wall. Like 8,2. 00 feet bigger. That’s the altitude limit for the DJI Matrice 6. Best of luck, Mr. President.[US Customs and Border Protection and Associated Press]. Offers news, comment and features about the British arts scene with sections on books, films, music, theatre, art and architecture. Requires free registration. BibMe Free Bibliography & Citation Maker - MLA, APA, Chicago, Harvard. 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Dead: Mitsubishi i- Mi. EVUnlike some other hatchbacks that will be departing the US market, I don’t predict anyone pouring one out for the Mitsubishi i- Mi. EV. The automaker announced will discontinue the electric vehicle due to slow sales. The next- generation Ford Fiesta may not be coming to the United States because you didn’t buy…Read more Green Car Reports got an official statement from Erica Rasch at Mitsubishi Motors North America who confirmed that “2. Mi. EV, and all available retail units have been sold.”According to Green Car Reports, the i- Mi. EV was technically the first mass- market electric car. Mitsubishi was testing fleets of them in Japan in 2. Tesla launched its roadster and the i- Mi. EV was on sale before the Nissan Leaf hit showrooms in 2. Despite its place in history, there weren’t too many positive qualities about the i- Mi. EV. It looked like an insect mated with a golf cart and had about the same amount of range. The i- Mi. EV would run out of juice in about 6. With the electric motors pumping out the equivalent of about 6. Mi. EV was also one of the slowest accelerating cars on the market doing the casual jaunt to 6. From millions of real job salary data. 0 salary data. Average salary is Detailed starting salary, median salary, pay scale, bonus data report. Izhevsk is the capital city of the Udmurt Republic, located between Volga and the Urals. Its population is more than 650 thousand people, the national. Tickets for Concerts, Sports, Theatre and More Online at TicketsInventory.com. At the time, the i- Mi. EV was also the cheapest EV you could buy with a starting price of just under $3. Mitsubishi will now focus its electric vehicle efforts on the Outlander Plug- In hybrid, which is the only crossover in its segment that offers a plug- in option, though no one seems to notice. 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Double- click the sheet tab, and type the new name. “The visionary starts with a clean sheet of paper, and re-imagines the world” – Malcolm Gladwell This post provides a complete guide to using the Excel VBA. Hello all i have written this code to copy a sheet ("first") and paste it i want to rename the worksheet i.e report1 then to increment to report2 etc i have got the. Right- click the sheet tab, click Rename, and type the new name. Use the keyboard shortcut Alt+H > O > R, and type the new name. Important: Worksheet names cannot: Be blank.
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